Henriette Pilegaard and Bente Klarlund Pedersen
نویسندگان
چکیده
once daily on expression of the PGC-1 family muscle: no effect of training twice every second day vs. is downregulated by training in human skeletal β PGC-1 You might find this additional info useful... physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied
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LIF is a contraction-induced myokine stimulating human myocyte proliferation.
The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine functioning in an autocrine fashion to activate gene regulation of human muscle satellite cell proliferation. Skeletal muscle LIF expression, regulation, and action were examined in two models: 1) young men performing a b...
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Section of Molecular Physiology, Department of Nutrition, Exercise and Sports (NEXS), 7 University of Copenhagen, Copenhagen, Denmark, The Centre of Inflammation and Metabolism 8 and The Centre for Physical Activity Research, Department of Infectious Diseases and CMRC, 9 Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, 10 Centre for Inflammation and Met...
متن کاملPGC-1beta is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family.
We hypothesized that the peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) family of transcriptional coactivators (PGC-1alpha, PGC-1beta, and PRC) is differentially regulated by training once daily vs. training twice daily every second day and that this difference might be observed in the acute response to endurance exercise. Furthermore, we hypothesized that expression lev...
متن کاملNitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle.
Previous studies have described the magnitude and time course by which several genes are regulated within exercising skeletal muscle. These include interleukin-6 (IL-6), interleukin-8 (IL-8), heme oxygenase-1 (HO-1), and heat shock protein-72 (HSP72), which are involved in secondary signaling and preservation of intracellular environment. However, the primary signaling mechanisms coupling contr...
متن کاملEndurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle.
Contracting skeletal muscle expresses large amounts of IL-6. Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to...
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